Sildenafil Citrate(Viagra) was originally developed in 1991 as a treatment for angina, orchest pain.The drug, marketed under the name Viagra, received FDA approval as a treatment for erectile dysfunction in March 1998, and since that time it has been prescribed for more then 20 million men worldwide. It was the first oral medication approved by ED treatment and selling by Buy Viagra Online. Viagra is a vasodilator, a drug that has the effect of dilating the blood vessels. It works by improving blood circulation to the penis, and by enhancing the effects of nitric oxide, the agent that relaxes the smooth muscle of the penis and regulates blood vessels during sexual stimulation, allowing the penis to become engorged and achieve an erection.
The average recommended dose of Viagra is 50 mg.
It comes in doses of 25 mg., 50 mg., and 100 mg to. The medication is taken approximately one hour before sexual activity is planned, and may remain effective for up to four hours. One drawback is that to be effective, it should be taken on an empty stomach. Also, high-fat foods can interfere with the absorption of Viagra. Viagra does not increase sexual desire. Sexual stimulation and arousal are required for it to be effective.
Many insurance plans cover the cost of Viagra, provided it is prescribed to treat erectile dysfunction. The pills cost approximately $10 each, and insurers may limit coverage to a specific number of pills each month.
The primary drawback to Viagra, which works about an hour after it is taken, it that the FDA cautions men with heart disease or low blood pressure to be thoroughly examined by a physician before obtaining a prescription. At least 130 men have died while taking Viagra. However, the FDA said the men—most over the age of 64—died of heart attack or stroke due to health problems exaggerated by sexual activity, not the drug itself.
Years ago, the standard treatment for erectile dysfunction was a penile implant or long-term psychotherapy. Although physical causes are now more readily diagnosed and treated, individual or marital counseling is still an effective treatment for ED when emotional factors play a role.
There are three prescription medications available in the United States to treat the physical causes of ED: sildenafil citrate (Viagra), vardenafil (Levitra), and tadalafil (Cialis).
They help about three-fourths of all men who try them in the general population. Several studies have indicated that their success rate in diabetic men may be slightly lower, averaging around 60-65%. All three pills work by enhancing the effects of nitric oxide. This chemical relaxes muscles in the penis to allow more blood to flow in. These pills do not cause an erection by themselves. Sexual stimulation is also required. Sildenafil or vardenafil should be taken about an hour before sex. Each is effective for roughly four hours. Tadalafil lasts for up to 36 hours. Men should not have sex more than once every 24 hours after using these drugs. Before Viagra’s approval in 1998, drug treatment of erectile dysfunction was limited to alprostadil (prostaglandin ), either injected into the penis or inserted as a pellet into the urethra. Sales of the three newer ED drugs reached $3.4 billion in 2004, according to the research firm IMS Health. In 2004, Viagra had about 66% of the market share for ED drugs compared to 19% for Levitra and 14% for Cialis.
In early 2003, a second prescription drug to treat erectile dysfunction, Levitra, was approved by the FDA. Like Viagra, Levitra helps increase blood flow to the penis and may help men with ED get and keep an erection. Once a man has completed sexual activity, blood flow to the penis should decrease and the erection should go away. Levitra should be taken approximately 60 minutes prior to sexual activity. In clinical trials, most patients were able to begin sexual activity before that time. A 2004 study showed that about 50% of men taking Levitra experienced a firm erection within 25 minutes and a small percentage in as quickly as 10 minutes. Studies also showed that Levitra improved erectile function in men who had other health factors, such as diabetes or prostate surgery.
Men taking nitrate drugs, often used to control chest pain (also known as angina), should not take Levitra. Men who use alpha-blockers, sometimes prescribed for high blood pressure or prostate problems, also should not take Levitra. Such combinations could cause blood pressure to drop to an unsafe level. Levitra is available in 2.5 mg, 5 mg, 10 mg, and 20 mg tablets and should be taken no more than once a day. The average cost per pill is about $10 and is covered by many insurance plans.
Cialis is the third oral drug prescribed to treat erectile dysfunction, approved by the FDA in November 2003. Its most notable difference from Viagra and Levitra, which work for about four hours, is that Cialis works for up to 36 hours. Cialis helps increase blood flow in the penis when a man is sexually stimulated. It can help men with ED get and keep an erection satisfactory for sexual activity. Once a man has completed sexual activity, blood flow to his penis decreases, and his erection goes away. Cialis is clinically proven to improve erectile function in most men with ED, including those with mild, moderate or severe ED.
The most common side effects with Cialis are headache, upset stomach, back pain, and muscle aches. These side effects usually go away after a few hours. Patients who get back pain and muscle aches usually get it 12 to 24 hours after taking Cialis. Back pain and muscle aches usually go away by themselves within 48 hours.
Cialis comes in 5 mg., 10 mg. (the recommended starting dose), and 20 mg. tablets. The average cost per tablet is about $10 and it is covered by many insurance plans. Since the absorption of Cialis is not affected by food or high-fat foods, it does not need to be taken on an empty stomach. Studies show that in most men, Cialis begins working in about 30 minutes and may be taken up to once per day by most patients.
Viagra is a drug used to correct the problems of sexual impotence or erectile dysfunction.
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It is estimated that up to 30 million American men frequently suffer from ED and that it strikes up to half of all men between the ages of 40 and 70. Doctors used to think that most cases of ED were psychological in origin, but they now recognize that, at least in older men, physical causes may play a primary role in 60% or more of all cases. In men over the age of 60, the leading cause is atherosclerosis, or narrowing of the arteries, which can restrict the flow of blood to the penis. Injury or disease of the connective tissue, such as Peyronie’s disease,may prevent the corpora cavernosa from completely expanding. Damage to the nerves of the penis from certain types of surgery or neurological conditions, such as Parkinson’s disease or multiple sclerosis, may also cause ED. Men with diabetes are especially at risk for erectile dysfunction because of their high risk of both atherosclerosis and a nerve disease called diabetic neuropathy.
Some drugs, including certain types of blood pressure medications, antihistamines, tranquilizers (especially before intercourse), and antidepressants known as selective serotonin reuptake inhibitors (SSRIs, including Prozac and Paxil) can interfere with erections. Smoking, excessive alcohol consumption, and illicit drug use may also contribute. In some cases, low levels of the male hormone testosterone may contribute to erectile failure. Finally, psychological factors, such as stress, guilt, or anxiety, may also play a role, even when the ED is primarily due to organic causes.
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February 16, 2010 11:12 am | 
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